What are the earliest signs of opiate withdrawal?

The earliest signs of opiate withdrawal typically begin within a few hours to a day after reducing or stopping opiate use. These early symptoms can vary in intensity but often include:

1. Anxiety and Restlessness: A common early symptom where individuals feel unusually anxious, agitated, or restless.

2. Runny Nose and Watery Eyes: Similar to symptoms of a cold, the nose may run and eyes may water.

3. Yawning: Frequent yawning is a typical early sign of withdrawal.

4. Sweating: Increased sweating, often profuse, can start early in the withdrawal process.

5. Muscle Aches and Pains: Mild muscle aches and discomfort may begin to set in.

6. Insomnia: Difficulty sleeping or changes in sleep patterns can occur.

7. Loss of Appetite: Decreased interest in food or changes in eating habits.

These symptoms generally start to appear within the first 6-12 hours for short-acting opiates (like heroin or immediate-release oxycodone) and might take a bit longer for longer-acting opiates (like methadone or extended-release formulations). As withdrawal progresses, symptoms can intensify and include gastrointestinal issues (such as diarrhea and nausea), chills, and more severe physical discomfort.

If you or someone else is experiencing withdrawal, it's important to seek medical advice. Withdrawal can be challenging and potentially dangerous, so professional support is often necessary to manage symptoms and ensure safety.